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Modelling of the solubility of aqueous biphasic systems based on ethyl lactate

Aqueous two-phase systems based on ethyl lactate is an innovative technique to separate biomolecules that
combines the advantages of liquid-liquid extraction and hydrophilic biorenewable solvent. Due to the
complexity of these systems, rigorous models based on theory are not available. Therefore, the empirical
equation given by Merchuk is usually used to describe binodal curves. However, Merchuk’s equations provide a
poor extrapolation ability. Therefore, the aim of this work is the analysis of other equations, comparing the
models reported in the literature and proposing alternative equations to improve accuracy or to reduce the
mathematical complexity. The research objectives of this project are: i) To compile a database containing
experimental data of solubility of nine aqueous biphasic systems based on ethyl lactate; ii) To select statistical
criteria to be used for the selection of models; iii) To fit various empirical models to experimental data; iv) To
analyse and compare the effectiveness of empirical models, allowing discussion of the advantages and
disadvantages of each equation.
2 websites with important data:
https://www.sciencedirect.com/science/article/abs/pii/S0040603112004698
https://www.sciencedirect.com/science/article/abs/pii/S0378381216300048

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